伊波拉病毒藥物對2019新型冠狀病毒有療效？

這裡是專利網站，就談談最近披露可能對2019年新型冠狀病毒引發的肺炎（簡稱：2019-nCoV，俗稱武漢肺炎、武漢病毒（為了方便理解，有些網站寫著"Wuhan Virus"，有些則寫為"Coronavirus"）, updated on Feb. 3, 2020）有療效的伊波拉病毒藥的新聞與其中專利。

伊波拉病毒藥物對2019年新型冠狀病毒可能有療效的報導：
（中文）https://technews.tw/2020/02/03/anti-ebola-drugs-work-effective-cures-appear-in-the-u-s/
（英文）https://www.scmp.com/tech/science-research/article/3048579/coronavirus-case-us-treated-experimental-gilead-drug-may-spur

這裡提到美國Gilead Sciences公司的一款針對依波拉病毒的藥「Remdesivir」可能對2019年新型冠狀病毒感染的肺炎有效！然而，「Remdesivir」並未被批准上市，甚至都沒有獲得安全性（對人）與有效性（對病）的認證，但顯然FDA（美國食品藥物局）對緊急事件有權在評估後（有過去相關病毒的數據，如SARS, MERS）可使用這類實驗性的藥品進行對人投藥，結果呈現是染病的人在一天後竟然幾乎完全好了！

"Remdesivir is not yet licensed or approved anywhere globally and has not been demonstrated to be safe or effective for any use. At the request of treating physicians, and with the support of local regulatory agencies, who have weighed the risks and benefits of providing an experimental drug with no data in 2019-nCoV, Gilead has provided remdesivir for use in a small number of patients with 2019-nCoV for emergency treatment in the absence of any approved treatment options."

Gilead Sciences這間公司的報導：

https://www.gilead.com/news-and-press/company-statements/gilead-sciences-statement-on-the-company-ongoing-response-to-the-2019-new-coronavirus

美國國家藥物資料庫中「Remdesivir」的資料：
https://pubchem.ncbi.nlm.nih.gov/compound/Remdesivir




藥品「Remdesivir」相關專利如下，顯然要動用藥品就需要「強制授權」，或是相關法規支持。如：US9949994






相關美國專利：
US2018346504
CRYSTALLINE FORMS OF (S)-2-ETHYLBUTYL 2-(((S)-(((2R,3S,4R,5R)-5- (4-AMINOPYRROLO[2,1-F] [1,2,4]TRIAZIN-7-YL)-5-CYANO-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHOXY) (PHENOXY) PHOSPHORYL)AMINO)PROPANOATE

US9949994
METHODS FOR TREATING FILOVIRIDAE VIRUS INFECTIONS

US9724360
METHODS FOR TREATING FILOVIRIDAE VIRUS INFECTIONS

US2019083525
COMPOSITIONS COMPRISING AN RNA POLYMERASE INHIBITOR AND CYCLODEXTRIN FOR TREATING VIRAL INFECTIONS

US2017071964
METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS

US2016122356
METHODS FOR THE PREPARATION OF RIBOSIDES

US2018311263
METHODS FOR TREATING FILOVIRIDAE VIRUS INFECTIONS

其他：查到伊波拉病毒比較有意思的資料如下：


https://hopkinsbio.org/biotechnology/ebola-outbreak-biological-patents/


updated on Feb. 4, 2020
補充一些新聞：
- https://www.reuters.com/article/us-health-china-gilead-sciences/gilead-working-with-china-to-test-ebola-drug-as-new-coronavirus-treatment-idUSKBN1ZU2RX
- https://edition.cnn.com/2020/02/03/investing/gilead-sciences-coronavirus-stock/index.html
- https://www.bioworld.com/articles/432804-gileads-remdesivir-enters-china-phase-iii-trial-to-fight-coronavirus

Ron